Wow, I never really researched pellets. I dont think I could ever get used to having something just sitting there under my skin. That would drive me insane....Like that chip thing in demolition man. Where the little thing was under his skin and he was scratchin it. I have been on HRT for a lil over 5 Years. I started out with pills the first 4 years. And only until about a year ago I switched to IM injection. Now Estrogel and IM Injections I do. Pills some times to keep E levels steady. I have not researched pellets much, But I know, All the types of administration has it pros and cons. The only thing that can really be done is to experiment until the best balance between both physical and financial assests presents itself.