Gene editing strategy eliminates HIV-1 infection in live animals

[jesi_j]

Just read about this, although HIV is pretty difficult to transmit its something that most of us all fear and hopefully get tested for regularly. do you guys think a Hiv cure would change sexual behaviours in anyway?

https://www.sciencedaily.com/releases/2017/05/170501112514.htm

[KelliBlueEyes]

I am often pleasantly surprised by the news that gets shared on this site. Thank you so much for sharing this.

Probably trans attracted men are not aware that according to the CDC 22% (or approximately 1 in 5) trans women are statistically HIV-positive. They site many reasons for this.

https://www.cdc.gov/hiv/group/gender/transgender/

Maybe things are different among other subcultures here in the United States, but the CDC claims higher rates of infection among certain groups, and in the south.

To me it seems like condom use is pretty prevalent, and testing widespread at least here in the north east. For example, I get tested for all STI's every month with the labs for my hormones, it's easy and convenient to do this.

Hopefully drug companies will be motivated, even if by their intention to profit, to find a cure for this disease.

[natina]

I reported on Crispr before

http://www.hungangels.com/vboard/showthread.php?101637-Crispr-and-rewriting-the-code-of-life

[jesi_j]

I reported on Crispr before

http://www.hungangels.com/vboard/showthread.php?101637-Crispr-and-rewriting-the-code-of-life

its great to see CRISPR/CAS9 is taking gene editing by storm going from a concept to actually clearing latency in animals, seems they are conducting preclinical trials for cancer causing HPV/hep/ and prob the most common hsv1/hsv2 said to be a 6 billion dollar market if it works. great news for us all if it means we can play safer.

[nysprod]

This is years and perhaps even decades away from being used in humans, if it ever happens.

[lifeisfiction]

This is years and perhaps even decades away from being used in humans, if it ever happens.

Yep, it is difficult to replicate results in animals. On many occasions they have cured disease in animals, but the toxicity is too and high and dangerous for humans (not for animals surprisingly) or other various reasons. I always look at the phase I and phase II results as good indicator of a treatment's potential. Hopefully, with some of the research I read they're getting closer to finding out how to flush HIV out form hiding. If they can do that, they could kill it off. Its penchant for hiding in all parts of the body makes it difficult to fully eliminate.

[jesi_j]

i figured it may be a while before human trials, there was mention of more animal trials in the papers. Decades from human trials is unrealistic, China already used CRISPR in human trial October 2016 for a lung cancer treatment. future treatments will go through less hurdles to test. A biomedical duel is currently in progress between China and the United States, which is important since competition usually improves the end product and their is also an element of urgency given these solutions are worth multi billion dollar per product....everyone wants a piece of that cake. a preventive vaccine may beat them to it. best of luck to them i hope they solve the issue and help those who carry any burden of disease.

[lifeisfiction]

i figured it may be a while before human trials, there was mention of more animal trials in the papers. Decades from human trials is unrealistic, China already used CRISPR in human trial October 2016 for a lung cancer treatment. future treatments will go through less hurdles to test. A biomedical duel is currently in progress between China and the United States, which is important since competition usually improves the end product and their is also an element of urgency given these solutions are worth multi billion dollar per product....everyone wants a piece of that cake. a preventive vaccine may beat them to it. best of luck to them i hope they solve the issue and help those who carry any burden of disease.

China does not adhere to legal ethics in the biomedical field as the may other countries rigorously do. In fact, there are numerous reports of their willingness to overlook certain medical protocols in pursuit of medical advancement. Furthermore, China has and continues the practice of organ harvesting from prisoners, particularly prisoners of conscience. Such practices provides information in violation of human rights and disregards safety protocols capable of protecting and promoting proper scientific methodologies While some hope that under President Xi many of these practices will change from former President Zimen. I see his actions as a way to solidify his control over the communist party and to remove his predecessors remaining faction (President Xi's crackdown on corruption campaign removing former Zimen supporters) and the masking/crude patching of China's turbulent stock market provides some grounds to doubt the full medical advancements some Chinese (under the guise of the Chinese government) companies are claiming. That's just my opinion.

[natina]

editing the genome to remove aids and cancer



Pitting the weaponry of a bacterium against the cunning of a virus


http://www.dailymaverick.co.za/article/2016-04-05-crispr-vs-hiv-

pitting-the-weaponry-of-a-bacterium-against-the-cunning-of-a-virus/

Editing HIV out of our genome with CRISPR
UMMS scientists seek ways to use powerful gene editing tool to excise latent HIV virus.

http://www.umassmed.edu/news/news-archives/2015/04/editing-hiv-out-of-our-genome-with-crispr/

https://en.m.wikipedia.org/wiki/editing

the genome to remove aids and cancer



Pitting the weaponry of a bacterium against the cunning of a virus

http://www.dailymaverick.co.za/article/2016-04-05-crispr-vs-hiv-

pitting-the-weaponry-of-a-bacterium-against-the-cunning-of-a-virus/

Editing HIV out of our genome with CRISPR
UMMS scientists seek ways to use powerful gene editing tool to excise latent HIV virus.

http://www.umassmed.edu/news/news-archives/2015/04/editing-hiv-out-of-our-genome-with-crispr/

https://en.m.wikipedia.org/wiki/CRISPR

[adfan]

Hiv has never been proven to exist

[GroobySteven]

Hiv has never been proven to exist

Tell that to my friends who died of AIDS. Dimwit.

[jesi_j]

sorry to hear this grooby, some of the mice had humanised immune cells....Partially humanised mice are now fairly common research tools. it will be interesting to see if this works as CRISPR has many uses. i also read an article about the potential future use of CRISPR in Transgender people however there was also an argument about ethics....i cant find the link now but who knows whats possible...

[adfan]

Tell that to my friends who died of AIDS. Dimwit.

Stop trying to be a e bully cause you have mod powers. Nothing was mentioned about aids it was hiv. HIV has never been isolated in a blood test therefore it does not exist. Mainstream aka lamstream the money making killing machine has made a ton of bread off the whole hiv bogus test. If mainstream science ever admits the test was bogus they would sued for billions. Plenty of holistic dr's have cosgined the hiv myth and full blown aids has been reversed using natural protocols.

https://www.youtube.com/watch?v=cl6ceSa-1pU

https://www.youtube.com/watch?v=NErSTKIukxU

https://www.youtube.com/watch?v=HYKcds8Y6VU


^^ this is real science unlike the garbage mainstream science brainwashes the masses with.

[GroobySteven]

Stop trying to be a e bully cause you have mod powers. Nothing was mentioned about aids it was hiv. HIV has never been isolated in a blood test therefore it does not exist. Mainstream aka lamstream the money making killing machine has made a ton of bread off the whole hiv bogus test. If mainstream science ever admits the test was bogus they would sued for billions. Plenty of holistic dr's have cosgined the hiv myth and full blown aids has been reversed using natural protocols.



I'm not being a bully because 'I have mod powers'. I'm telling you, you are a dimwit because you are - and it's the wrong place for that post. Take of your tinfoil hat.

[DeseosEscandulosos]

HIV has never been isolated in a blood test therefore it does not exist.

This is a bizarre argument. HIV was isolated in human blood in 1983. It wasn't a "blood test", it was an attempt to isolate the virus. At this point, not only have we isolated HIV repeatedly, we've also identified the structure of all of its parts. We even know where the proteins bend when they fold. We've isolated different strains of HIV and we know exactly where on the RNA the differences occur.

The most common HIV tests test for antigens instead of testing for the virus itself. It's cheaper and easier to do it that way, and the tests are extremely reliable. But there are other tests that test for the virus directly, and they're becoming cheaper and more common.


full blown aids has been reversed using natural protocols.

Some studies have shown that some natural medicines, in combination with standard medicine, help with some unpleasant symptoms of AIDS, or in some cases may actually give the standard medicines a bit of a boost, but the studies are small, have methodological problems, and any effect is small. In any case, if the patient stops taking the prescribed anti-virals, the natural medicines alone won't stop the progress of AIDS.

[adfan]

I'm not being a bully because 'I have mod powers'. I'm telling you, you are a dimwit because you are - and it's the wrong place for that post. Take of your tinfoil hat.

Stop being a wanna tough guy u fat slob.. brainwashed slave

[adfan]

This is a bizarre argument. HIV was isolated in human blood in 1983. It wasn't a "blood test", it was an attempt to isolate the virus. At this point, not only have we isolated HIV repeatedly, we've also identified the structure of all of its parts. We even know where the proteins bend when they fold. We've isolated different strains of HIV and we know exactly where on the RNA the differences occur.

The most common HIV tests test for antigens instead of testing for the virus itself. It's cheaper and easier to do it that way, and the tests are extremely reliable. But there are other tests that test for the virus directly, and they're becoming cheaper and more common.



Some studies have shown that some natural medicines, in combination with standard medicine, help with some unpleasant symptoms of AIDS, or in some cases may actually give the standard medicines a bit of a boost, but the studies are small, have methodological problems, and any effect is small. In any case, if the patient stops taking the prescribed anti-virals, the natural medicines alone won't stop the progress of AIDS.

we've??? I deal with facts and u just follow the modern medicine killing machine like a blind sheep.

[Laphroaig]

we've??? I deal with facts and u just follow the modern medicine killing machine like a blind sheep.

Are you a member of the Flat Earth Society as well?...:whistle:

[sukumvit boy]

Gary Null is a very persuasive and personable guy , but a little nuts.
I started listening to his radio show " Natural Living with Gary Null" in the 1980's on WBAI FM public radio in New York City. His call-in show and message of healthful living was refreshing and not so radical in the 80's , but research has out-paced him.
10080291008030
http://en.wikipedia.org/wiki/Gary_Null

[adfan]

Gary Null is a very persuasive and personable guy , but a little nuts.
I started listening to his radio show " Natural Living with Gary Null" in the 1980's on WBAI FM public radio in New York City. His call-in show and message of healthful living was refreshing and not so radical in the 80's , but research has out-paced him.
10080291008030
http://en.wikipedia.org/wiki/Gary_Null


Not try clown but shitipedia is proven fountain of misinformation, nulls stats are proven so narrow minded asswipes like u will never comprehend this.

[adfan]

Are you a member of the Flat Earth Society as well?...:whistle:

Nope try again sheep

[kaientai]

So adfan the friends I had who died because of AIDS or HIV related troubles that is fake acording to you. Let alone what happened to Freddy Mercury . Adfan you are disgusting and should be banned for life

[LondonLefty]

Nope try again sheep

You're a total idiot. There is a mass of science when it comes to HIV, it does exist. Rather than look at proper science, you are cherry picking at pseudo science and calling people names. Do you really believe that every single doctor, scientist, virus expert, epidemiologist etc. is in cahoots and making it up, yet one quack says it doesn't exist and a few Youtube videos give out some factoids, and you're sold?

[adfan]

You're a total idiot. There is a mass of science when it comes to HIV, it does exist. Rather than look at proper science, you are cherry picking at pseudo science and calling people names. Do you really believe that every single doctor, scientist, virus expert, epidemiologist etc. is in cahoots and making it up, yet one quack says it doesn't exist and a few Youtube videos give out some factoids, and you're sold?

so you created this new username to spew this misinformation? go fuck yourself asshole

[adfan]

So adfan the friends I had who died because of AIDS or HIV related troubles that is fake acording to you. Let alone what happened to Freddy Mercury . Adfan you are disgusting and should be banned for life

I also have friends and family that died of full blown aids and that doesnt change the fact modern medicine is on some political bullshit. Have you ever done research on any on this you narrow minded piece of shit? Of course not but you know how to come on a message board and write bullshit. fuck you

[jesi_j]

I also have friends and family that died of full blown aids and that doesnt change the fact modern medicine is on some political bullshit. Have you ever done research on any on this you narrow minded piece of shit? Of course not but you know how to come on a message board and write bullshit. fuck you

how have you had friends and family die of aids when you say aids is a myth?

anyway on another note when i initially thought we were many years away from CRISPR being trialled in Humans for viral use it looks like trials are actually starting later this year http://www.excisionbio.com/pipeline.